宫腔镜检查结合P21WAF1、CyclinE表达早期诊断子宫内膜癌的临床研究
摘要：目的探讨宫腔镜及抑癌基因P21WAF1、细胞周期素E(CyclinE)表达对子宫内膜癌的早期诊断的意义。方法宫腔镜检查682例患者，选取其中10例正常子宫内膜，14例子宫内膜不典型增生，27例子宫内膜癌应用免疫组织化学法检测P21WAF1及CyclinE基因表达。结果宫腔镜及病理检查确诊27例子宫内膜癌(3.96%)；三种组织比较，P21阳性表达率逐渐降低，CyclinE阳性表达率逐渐增高，差异均有显著性。结论宫腔镜定位活检结合P21WAF1及CyclinE表达可早期诊断子宫内膜癌。
关键词：宫腔镜；子宫内膜癌；P21WAF1；CyclinE
StudyonsignificanceofhysteroscopyandexpressionofP21WAF1,CyclinEinearlydiagnosisofendometrialcarcinoma.KONGYu-ling，YUANJi-rong,LIBen-ying.(DepartmentOfObstetricsandGynecology,TheSecondHospitalAffiliatedHarbinMedicalUniversity,Harbin,150086)
Abstract:Objective:TodetectthesignigicanceofhysteroscopyandexpressionofP21WAF1,CyclinEinearlydiagnosisofendometrialcarcinoma.Methods:Thediagnostictechniqueofhysteroscopywasusedtoexanine682patients.ImmunohistochemistrytestwasusedtoexaminetheexpressionofP21WAF1andCyclinEin10caseofnormalendometrium,14caseofuterusatypicalhyperplasiaendometriumand27caseofendometrialcarcinoma.Results:27endometrialcarcinomapatients(3.96%)weredigonsiseddefinitelybythecombineduseofhysteroscopyanddirectedbiopsies.Inthethreeendometriumtissues,thepositiveexpressionrateofP21WAF1islowersignificantly;thepositiveexpressionrateofCyclinEishighersignificantly.Conclusion:Thecheckofhysteroscopy,colposcopyandtheexpressionofP21WAF1andCyclinEplayandimportantroleinearlydiagnosisofendometrialcarcinoma.
Keywords:Endometrialcarcinoma;Hysteroscopy;P21WAF1;CyclinE
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