宫腔镜结合C-erbB-2、nm23及ER表达对子宫内膜癌早期诊断意义
摘要：目的 探讨宫腔镜结合C-erbB-2、nm23及ER表达在子宫内膜癌中的诊断意义。方法 宫腔镜检查2400例患者，对筛查出的35例子宫内膜癌、10例内膜不典型增生及10例正常内膜，用免疫组化SP法检测C-erbB-2、nm23和ER表达。结果 ：C-erbB-2、nm23、ER阳性表达率依次为74.29%、51.43%、54.29%；50%、30%、60%；30%、10%、90%。三者nm23、ER阳性表达率明显升高，差异有显著性(P﹤0.05)； C-erbB-2阳性表达率明显降低，差异有显著性(P﹤0.05)。宫腔镜定位活检确诊子宫内膜癌35例（35/2400），占1.46%。结论 宫腔镜直观病灶，结合C-erbB-2、nm23及ER表达对内膜癌早期诊断有意义。
关键词：宫腔镜；C-erbB-2；nm23；ER；子宫内膜癌
The significance of hysteroscopy combined with the expression of C-erbB-2、nm23 and ER in early diagnostic of endometrial carcinoma. YUAN Ji-rong, XIAO Bing, DU Ya-li. (Department of Gynecology and Obstetrics, The second Affiliated Hospital of harbin Medical University, Heilongjiang Harbin 150086,China)
Abstract: Objective: To detect the significance of hysteroscopy combined with the expression of C-erbB-2、nm23 and ER in early diagnostic of endometrial carcinoma. Methods: 2400 patients were examined by hysteroscopy, the expression of C-erbB-2、nm23 and ER were examined in SP immunohistochemical method among the 35 cases of endometrial carcinoma\10 cases of uterus atypical hyperplasia endometrium and 10 cases of normal endometrium .Results: the positive expression rates of C-erbB-2、nm23 and ER is74.29%、51.43% 、54.29%;50 % 、30%、60%；30%、10%、90%;respectively. in the three endometrium tissues, the positive expression rates of nm23 and ER is higher significantly(p﹤0.05);the positive expression of C-erbB-2 is lower significantly(p﹤0.05). using hysteroscopy combined with directed biopsies showed 35 cases of endometrial carcinoma（35/2400）, the percentage is 1.46%。Conclusion: Hysteroscopy can be used to observe the endometrial focusis and biopsies ,which combined with the expression of C-erbB-2、m23 and ER have great significant in early diagnosis of endometrial carcinoma.
Key words: Hysteroscopy ；C-erbB-2protein；nm23 genes；estrogen receptor；Endometrial Carcinoma
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